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Medicinal plant may harbour HIV
cure
Washington:
A new UCLA AIDS Institute study has found that
a chemical from the Astragalus root, frequently used
in Chinese herbal therapy, may help in the fight against
HIV. Like other kinds of cells, immune cells lose
the ability to divide as they age because a part of
their chromosomes known as a telomere becomes progressively
shorter with cell division. As a result, the cell
changes in many ways, and its disease fighting ability
is compromised. But the new study has shown that the
chemical, TAT2, can prevent or slow this progressive
telomere shortening. "This has the potential to be
either added to or possibly even replace the HAART
(highly active antiretroviral therapy), which is not
tolerated well by some patients and is also costly,"
said study co-author Rita Effros, a professor of pathology
and laboratory medicine at the David Geffen School
of Medicine at UCLA and member of the UCLA AIDS Institute.
The researchers tested TAT2 in several ways. First,
they exposed the CD8 T-cells from HIV-infected persons
to TAT2 to see if the chemical not only slowed the
shortening of the telomeres but also improved the
cells' production of soluble factors called chemokines
and cytokines, which had been previously shown to
inhibit HIV replication. And they found that it did.
They then took blood samples from HIV-infected individuals
and separated out the CD8 T-cells and the CD4 T-cells
- those infected with HIV. They treated the CD8 T-cells
with TAT2 and combined them with the CD4 T-cells in
the dish-and found that the treated CD8 cells inhibited
production of HIV by the CD4 cells. "The ability to
enhance telomerase activity and antiviral functions
of CD8 T-lymphocytes suggests that this strategy could
be useful in treating HIV disease, as well as immunodeficiency
and increased susceptibility to other viral infections
associated with chronic diseases or aging," the researchers
said The study is to be published in the Nov. 15 print
edition of the Journal of Immunology.
- Nov
11, 2008
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