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Seaweeds may be the panacea for all ills

      Washington: Researchers at the Georgia Institute of Technology have discovered 10 new molecular structures found in a species of red seaweed along the Fijian coral reef that have potential to kill cancer cells, bacteria and the HIV virus. According to a study published in the recent issue of the American Chemical Society Journal Organic Letters, two of these natural compounds exhibit anti-bacterial activity. The compound that was isolated in the greatest abundance killed human tumor cells by inducing programmed cell death (called apoptosis), a mechanism that is promising for development of new anti-cancer drugs. Researcher Julia Kubanek and her colleagues collected baseball- sized samples of Fijian coral reef species that exhibit unusual growth or behavioral phenomena. Among their collection were soft corals, marine sponges, slugs, and green, red and brown seaweeds. "These molecular structures are curious in the way carbon atoms are attached. It's very unusual. They represent a new category of organic molecules. It's exciting as a biochemist to observe that living organisms have evolved the ability to synthesize such unique and exotic structures compared to other molecules typically produced by seaweeds," said Kubanek. "There are chemical differences among populations of this seaweed species, even though two of the sites where it was collected are only about 2 kilometers apart. This shows us there are small, but valuable differences within species, and this genetic biodiversity is important to protect as a resource for the future," she said. Researchers have been analyzing extracts from about 200 marine plant and invertebrate animal samples they collected from the Fijian coral reef in June 2004 with the permission of the Fijian government and local resource owners. "Marine organisms make molecules for their own purposes that we might co-opt for our own use as pharmaceutical agents. The organisms' purposes include defense against predators, the ability to fight diseases, and the production of chemical cues, such as those used for sex recognition," Kubanek explained.
Oct 13, 2005

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