NEW DELHI, June 14: The Health Ministry on Saturday issued revised guidelines for the clinical management of coronavirus (covid) even as the number of cases has crossed 3 lakh. The new protocol allows use of Hydroxychloroquine (HCQ) in early stages of detection of symptoms and antiviral drug Remdesivir in moderate cases.

Others are: Tocilizumab, convalescent plasma and glucocorticoids.

Tocilizumab, a drug that modifies the immune system or its functioning, and convalescent plasma have also been approved for use among coronavirus patients. While ECG has been recommended before administering HCQ, Remdesivir is recommended for moderately sick patients likely needing oxygen. Azithromyzin has been dropped as a combination drug to be given alongwith HCQ.

Remdesivir has been contraindicated in renal and liver impairment, pregnant women, lactating mothers, children under 12 years of age. It is administered by injection, single dose first day 200 mg and 100 mg each subsequent four days.

Convalescent plasma therapy may be considered for patients with moderate illness with no improvement despite use of other drugs. In this therapy antibodies from the blood of a person who has recovered is taken and transfused to a coronavirus patient. This is said to boost up the the patient's immune system. Patients with immunoglobulin A deficiency or immunoglobulin allergy should not be given this. The patient should be watched for .progressive deterioration of oxygenation indicators.

Any infection or tuberculosis must be ruled out before administering Tocilizumab. In worsening cases of covid, glucocorticoids may be used.

"Several large observational studies with severe methodological limitations have shown no effect on mortality or other clinically meaningful outcomes... As such, the evidence base behind its use remains limited as with other drugs and should only be used after shared decision making with the patients while awaiting the results of ongoing studies,” the revised document said.

India today stands at a critical No 4 in the list of worst hit countries, next only to the US, Brazil and Russia, having steadily climbed from the bottom of 180 countries. Just in 10 days the case count has gone up from 2 lakh to 3 lakh on Saturday. There was a spike of 11,458 infections in a day on Saturday. The death toll too climbed to 8,884 with 386 new fatalities.

Maharashtra is leading among the worst-hit States with the number of cases crossing 1 lakh and the casualties nearing 4,000 while Gujarat came second, recording a toll of 1,415 and total cases at 22,527.

Five people were arrested from a banquet hall in Sector 51 Noida on Thursday where they were called to hold a rave party in a trap laid by the animal rights group, PFA. They named Yadav but he was not present.

Betting through Dubai-based Mahadev Book in India is conducted through a countrywide network. Probes reveal that the online gambling is worth several millions and top politicians, officials and celebs have been beneficiaries.

TAILPIECE: Polling dates for some States are round the corner. Top politicians have begun their acrimonious debate who looted more, even as Mahadev is washing their dirty laundry in the open ghat. Come what may, one needs to seize power to amass "thy wretched pelf!" One simple question is, why else one should spend lakhs or crores to get elected! A question every Indian should ask to oneself at least once a day!

His inaction amounts to defeating the rights of the people of the State to welfare measures sought to be implemented through the Bills, the Kerala Government's petition submitted, while the State of Tamil Nadu remarked that its "Governor is acting as a political rival."

Tailpiece: Coming up back to back, the petitions in their totality seem to question the provision of Raj Bhavan, and not motives of a Governor as a person.

Hundreds of cars piled up behind the wreckage of crashes occurring one after other in backing up - continuous crashes to the rhythm of metallic clanks and bangs back to back. According to reports, some ops required 'Jaws of Life' to pull apart the mangled cars to save lives inside.

The pilots struggled with Emerson to thwart a shut-off as he reached for the T-handles (see pix). Later he admitted to police he had taken psychedelic mushrooms and had a "nervous breakdown."

Doctors reasoned how the incidence of heart attacks is spiking over time and advise the simple way to play safely is to take a break and rehydrate yourself.

But how come ten people, including children, die of cardiac arrest at Garba in 24 hours, and that at different places of Gujarat? Garba had been going on for six days, and every year it is celebrated.

The killing of a teacher in France by an Islamic radical last Friday is linked to the Israel-Hamas war in West Asia, say authorities.

Shocking news from the UK: Leading grocers have started bribing policemen with free food and drinks to persuade them to take action against shoplifters.

Shoplifting has risen by about 27 per cent in 10 major cities across the UK this year. The cost of retail crime last year was $2.15 billion. Besides, “We are seeing organised gangs threatening staff with weapons and emptying stores," Helen Dickinson, chief executive of the British Retail Consortium, said. Data shows that the police failed to respond to 73 per cent of serious retail crimes that included assault and abuse of workers, apart from shoplifting.

Isar Mohammad allegedly picked up a banana offered to Ganesh idol on Chaturthi at a makeshift temple in Delhi and consumed it.

Harris said hip-hop is “the ultimate American art form” that “shapes every aspect of American popular culture.” “Hip-hop culture is American culture,” she said in a talk at her official residence at the US Naval Observatory in Washington, D.C.

The social media had mixed reaction. There was much appreciation that she dances better than any VP in American history. But some called her "moves" as “cringe” while others did not like her pink pants - "pink pants don’t look good.” In fact, her ensembles have always been incongruous.

"Let’s see how the (Governor's) Vice-Chancellors are given salary." Mamata's extreme statements will put the Marxist Government in Kerala, which is also facing similar issues, to shame. Has she begun the countdown for a war on the streets?

It's true Mamata has come to see a conspiracy to demolish the established systems across the country, but lacks the ability to foresee what exactly is being pushed.

Brandishing a sword, Mahant Paramhans told reporters on Tuesday he himself will behead MK Stalin's son for his remarks against Sanatan Dharma in case nobody came forward to accept his offer he made in his video. Udhayanidhi reacted to the saint's Monday video, "I will speak more. I am the grandson of the artist who put his head on the rail track for Tamil Nadu."

Somanath elaborated, "I am an explorer. I explore the Moon. I explore the inner space. So it's a part of the journey of my life to explore both science and spirituality. So I visit many temples and I read many scriptures. So try to find the meaning of our existence and our journey in this cosmos. So it's a part of the culture that we are all built to explore, find out the inner self as well as outer self. So for the outer, I do science, for the inner I come to temples." (See videos)

Rao the mathematical legend had fathered the path-breaking Rao-Blackwell theorem, one of the most important theorems in mathematical statistics, at the age of 25. That brought him global fame. He is also famous for his Cramér-Rao Bound inequality theorem relating to quality of estimators in statistics which has had a profound bearing on applications of modern economics and several other diverse fields. Simply put, with the pioneering statistician computation became a tool to analyse even socio-economic challenges of modern times.

The alleged incident has received such a flash publicity that a standardised city's hugely middle class population will have second thoughts about eating outside for some time. Now everything on the table looks suspicious!

“All subjects directly connected to the people should be shifted to the State List. Particularly the subject of education. Only if this is done can cruel exams like NEET be abolished,” Stalin said. Education was moved from the State List to the Concurrent List with the 42nd Constitution Amendment made by the Central Government in 1976.

Decentralisation has been at the core of Tamil politics since the times of CN Annadurai. Stalin indicated there will be political changes in the offing.

TAILPIECE: While the Centre and the States are at loggerheads, it takes a different cognitive acumen to know that entrance tests are not the way for students' admission to courses.

As recently as Tuesday Craig Robertson had posted on Facebook: "Perhaps Utah will become famous this week as the place a sniper took out Biden the Marxist." Biden was scheduled to make his first visit to Utah as President Wednesday afternoon.

Maruti is recalling 87,599 S-Presso and Eeco vehicles to inspect and possibly replace parts in the steering system. All reputed companies around the world do recall their products when a defect comes to light.

Meanwhile, a question arises why just in about a year so many accidents have taken place involving Mercedes sent to India while the car has won safety awards abroad? In most cases, the vehicle collided with divider, while manoeuvring a turn. Was there a split second delay in the steering system coming to a grip when at high speed? Did anybody in India bother to study a pattern in several of these accidents that took place one after other?

Former Tata Sons chairman Cyrus Mistry died when his Mercedes-Benz-SUV hit a divider in Gujarat. Cricketer Rishabh Pant's Mercedes-Benz-SUV rammed a divider in Uttarakhand and smashed. It went up in flames but he escaped with injuries. Brother of PM Narendra Modi, Prahlad Modi's Mercedes-Benz-SUV met with a similar accident in Mysuru. And many more.

• Experts blame violation of the Visual Flying Rules (VFR) for most of the chopper crashes in the mountains as the leading cause. VFR means fly only visually - because of the lack of navigation aids in remote areas or unreliability of GPS-like aids in hilly terrains or a remote manipulation of instruments in cases of sabotage - as the topography plays havoc especially in the monsoon (mid-June to September).
• Even when VFR is followed, most crashes occur due to CFIT (Controlled Flight into Terrain) - that is, everything else is OK but the aircraft collides with hills or trees hidden by the clouds. This also occurs mostly in the monsoon.
• On Tueday with Manang, the chopper was brand new, pilot was highly experienced. But it hit an 'invisible' tree and then crashed against a hillside. This CFIT occurred when the pilot tried to dodge patches of clouds even as he was following the VFR.
• Simply put, everyone knows flying in the hills during the monsoon is risky, but the companies want to make more money in any which case. This type of tragedy is very frequently invited in the Indian hill State of Uttarakhand as well, where pilots are even made to fly without the mandatory rest.