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India approves Johnson's single-dose covid vaccine: Watch out for any side-effects
Those getting vaccinated need to be briefed about the side-effects, and the remedies, as many drugs and symptomatic therapies are contraindicated in the management of post-vaccination side-effects. Johnson's vaccine like AstraZeneca had produced blood clots in a few cases. These CVST patients also developed thrombocytopenia, which has an inverse relation to CVST. How to handle the complex issues? The US had paused Janssen but later resumed as the benefits of vaccination outweighed the AEFIs.

NEW DELHI, Aug 9: The American pharmaceutical firm Johnson & Johnson's covid vaccine, Janssen, has received Emergency Use Authorization (EUA) for immunisation in India. Union Health Minister Mansukh Mandaviya has announced.

"India expands its vaccine basket! Johnson and Johnson's single-dose COVID-19 vaccine is given approval for Emergency Use in India. Now India has 5 EUA vaccines. This will further boost our nation's collective fight against covid," he tweeted on Saturday.

The single-dose vaccine will be distributed in India by vaccine maker Biological E Limited which has an agreement with Johnson & Johnson. However, the price or the time when the vaccine will be made available is not yet known. The pharma got India's approval just a day after it applied for Emergency Use Authorisation (EUA).

Janssen is the fifth covid vaccine to receive EUA in India, the others being Serum Institute of India's Covishield (Oxford- AstraZeneca), Bharat Biotech's indigenous Covaxin, Russia's Sputnik V and US' Moderna. India, with a population of over 130 crore, has so far administered 50 crore doses of covid vaccine, either Covishield or Covaxin.

In the home country US, Johnson's is one of the three vaccines being used currently, the other two being Pfizer and Moderna. The advantage Johnson's has is that it is a one-dose vaccine while all the other 20 odd vaccines developed in the world across against covid are two-dose to be taken with a gap of several weeks. A single-dose vaccine can achieve herd immunity faster.

28 people reported blood clots by May

However, in early April, the US Government recommended pausing the Johnson vaccine for further study after six women who received it developed an adverse event of blood clots and one of them died. The women were aged 18 to 48 years. They developed the symptoms in 6 to 13 days. Later, the Centers for Disease Control and Prevention (CDC) decided to end the pause as the benefits outweigh the small number of AEFIs and the Food and Drug Administration (FDA) decided to add a warning label about blood clotting disorder. Thereafter vaccination resumed, after a two-week halt. By May, 9 million doses had been administered and the adverse event was noticed in 28 of them, and three of them died, according to the CDC.

Internal blood clots block blood flow causing thrombosis, and can be fatal. When there is an injury on our body a clot forms that prevents further bleeding. This is not of any consequence but an internal clot - due to many factors - in blood vessels can be. In the case of Johnson's vaccine, the clot formed in the blood vessels of the brain in all the first six women. The condition is called cerebral venous sinus thrombosis (CVST).

However, what is puzzling is that these women also developed thrombocytopenia, which has an inverse relation to CVST. The scientists examining the AEFIs say the strange episodes are surprising! Same was the AEFIs for AstraZeneca detected in Europe and some other countries leading to a pause in this case also. Some recipients developed CVST and low platelet counts at the same time! Both are viral carrier or vector vaccines. Russian Sputnik V also falls into this category. There have been no report of clots vis-a-vis the mRNA vaccines of Pfizer and Moderna.

Another contradiction eluding a scientific resolution is that about 20% of covid patients in the ICU are found to develop blood clots, leading to damage to vital organs! According to 'The Lancet - Haematology', the endothelial cells have a role in the clot formation in covid patients. These two types of blood clots and the common occurrences of thrombosis call for three different ways of therapy, and they can be contraindicated!

An argument in defence is, chances of getting clots in case you contract covid infection are more than in getting vaccinated.

The common AEFIs are:

  • Severe headache,
  • Backache,
  • Neurological Symptoms,
  • Severe abdominal pain,
  • Shortness of breath,
  • Leg swelling,
  • Tiny red spots on the skin (petechiae)

Who can be vaccinated:

  • The J&J vaccine, like the other vaccines, is also recommended for people above 18 years of age.
  • The WHO said the vaccine is safe and effective in people with comorbidities such as hypertension, chronic lung disease, significant cardiac disease, obesity and diabetes.
  • It can also be taken by those who have had covid.
  • This vaccine can be offered to breastfeeding women too.

Who should not be vaccinated:

  • It is not recommended for individuals with a history of anaphylaxis to any component of the vaccine.
  • It should also not be administered to one running temperature.

The vaccination booths should have adequate built-in arrangements to educate those getting vaccinated on what to do and what not to do after the vaccination. Although this is vital, mostly it is taken for granted. They also need to be briefed about the side-effects, serious and non-serious, and the remedies, as many drugs and symptomatic therapies are contraindicated in the management of post-vaccination side-effects.

The WHO Strategic Advisory Group of Experts (SAGE) on Immunisation had issued interim recommendations for the use of the Janssen in June last.

Janssen was found to have an efficacy of 85.4% against severe disease and 93.1 % against hospitalization, 28 days after inoculation.

Janssen is given as one dose (0.5 ml) intramuscularly unlike all other vaccines requiring two doses separated by a gap of several weeks.

Johnson vaccine needs less refrigeration requirements than the Moderna or Pfizer.

Janssen has also undergone review by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) and found to be safe for use.

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The incident has triggered a debate on social media whether the officer refused to take orders from a party leader or he was accused of any corruption, some netizens justifying the handling in either case, that Ratnakar was blocking public welfare work! It is true the Govt machinery has been the enemy Number One of the people of this country, existing for itself and for these politicians, for well over seven decades. India will never make an inch of progress - real progress, not make-believe-progress - unless and until this machinery is eliminated.

The irony lies in her illustration of her experiences in the country she has been living in for the last four years. What it really is!

ANALYSIS: There have been cases of Britons going to Switzerland to get rid of a miserable life. Now once the House of Lords also passes the Terminally Ill Adults (End of Life) Bill, terminally ill Britons can call it quits with the help of a medical practitioner here itself. But the measure when comes into practice, will have very serious social consequences, it is feared. There won't be comparisons, even as tropes in Latin American folklores. The worst case scenario is of those who are not terminally ill also trying to misuse the provision to leave this world early when life with dignity is not available. But that is, in fact, a political question and not a moral imbroglio!

The CCTV footage and the video circulating on social media do not indicate any serious abnormalities in takeoff or descent, it has been confirmed. The disaster is becoming curiouser and curiouser. The flight path was not curvy. And the aircraft maintained a steady, gliding descent with its nose straight and the wings perfectly level. The pilot's distress call does not specify what prevented lift and climb-out. Here are some expert opinions. The sole purpose is to raise travellers' awareness about air travel.

Many of the victims were charred beyond recognition, making identification difficult. Three hundred nineteen body parts have been sent for DNA matching with relatives to determine the identities.

  • The Udhampur-Srinagar-Baramulla line provides Kashmir with all-weather connectivity and integrates the Valley with the rest of India.
  • The saying 'Kashmir to Kanyakumari' is now a dream come true.
  • The Chenab bridge on the line, an engineering marvel, is the world's highest railway bridge, taller than the Eiffel Tower. (Video: File)

A comment on social media on Kanimozhi's answer on the question of national language read: "Daughter of Kalaignar M. Karunanidhi. Delivered the Birthday Present to her Father!!" (Karunanidhi was born on June 3, 1924) (Today's headlines )

Trump said, "Elon is not really leaving" and will be "back and forth" to the White House because DOGE is his "baby." "I think he’s going to be doing a lot of things.”

Musk wrote: "My scheduled time as a Special Government Employee comes to an end... The @DOGE mission will only strengthen over time as it becomes a way of life throughout the government." Now on it will be on auto-pilot.

PROGNOSIS: DOGE was prematurely born to protect the country by aborting an impending socio-economic disaster which very few people could see coming.

Although its immediate job was to save American taxpayers billions by slashing waste, eliminating fraud, cutting Government bloat and ensuring utmost efficiency in administration for the good of the people. (Today's headlines )

"Coming from a system like in England, empowering," she says she never had an idea of this sort of experience... being asked to “socialise with middle-aged men” who financed the event...humiliating...

Originally from Junagadh, Gujarat, Pataudi was relocated to Etawah Lion Safari in September 2019 before being transferred to Gorakhpur Zoo in 2021. Recently it was receiving treatment for pancreatic and liver infections. After tigress Shakti died in the zoo on May 7 due to bird flu, Pataudi was shifted to Kanpur. Some birds are also reported to have died mysteriously around Gorakhpur. All zoos in UP are closed for fear of a bird flu outbreak.

Three other animals too had died - a tiger, a leopardess and a female wolf. Wolf Bhairavi died last Saturday, leopardess Mona died the Thursday before that and tiger Kesari died on March 30. Some of them had Shakti's symptoms but the cause of death has not been confirmed yet.

As tourist inflow is an indicator of normalcy returning to an erstwhile terrorist infested Valley, the Government has been trying hard to make everything travel-friendly, launching lot many projects and bringing Kashmir on the national rail map that physically completes the process of Kashmir's integration with the rest of India. And that defeats the designs of Pakistan eyeing Kashmir and simply explains a recrudescence of terrorism in J&K.

The committee headed by justice Kurian Joseph will study Centre-State relations and make proposals to ensure foolproof separation of powers.

"It's a big victory not just for Tamil Nadu but for all Indian States. DMK will continue to struggle for and win State autonomy and Federal polity," Chief Minister MK Stalin said.

Of 2.08 km in length, it features 99 spans and a 72.5-metre vertical lift span that rises up to a height of 17 metres, facilitating smooth movement of ships while ensuring seamless train services to the holy town of Rameswaram on Pamban island.

ANALYSIS: There is a lot of hue and cry around the world over Trump's tariffs. But tariff, simply put, is a tax. But unlike tax, it affects the exporting country too. Domestic prices will go up for some time. Nothing more will happen, good or bad!

What motivated Trump's newfound policy, apart from being a stunt to justify his existence in the White House, is a false realisation that increased tariff will make foreign goods prohibitive, thereby boosting local production, and create more jobs, and more prosperity will ring in! If that is true, India would have been shining by now: Producing own Rolls-Royce La Rose Noire Droptail and Scotch Whiskies! And what about coconut and palm oil by America! (Today's headlines )

PROGNOSIS: It looks a Real New Trump is emerging - courageous, balanced, powerful and disinterested. Determined to save his country from the cliff, he has done quite a few draconian things that will reduce the burden of debts of the Federal entity, like the golden handshake, stopping senseless funding, pulling out of a worthless WHO. Shutting the Education Department is another. On the other hand, running it is also not the Centre's job either (We will convincingly elaborate it in the next chapter).

In India the scene is just the opposite. Centralisation is the core agenda and identity of the ruling dispensation without which it has no existence, or in other words, it exists for that set of schemes only. A realisation of this never dawned upon any Opposition party in 2014 or any time thereafter, what to talk of being able to see it coming 70 years ago! The consequence of all this violation of basic natural law of the universe we cannot predict.

THE AMERICAN CONUNDRUM: Political venom has migrated to top echelons in the US. It was reported last year NASA has become politicised, vitiated. But NASA refuted the charge. How Boeing developed a glitch but its unmanned return was smooth. When Suni-Wilmore were stranded last June, why the return was set for February? Because that comes only after January 20! SpaceX called the shots, for itself and for Trump. Then the mission was manipulated for March for a better bargain! In between, what made Elon Musk 'predict' during campaign if Kamala Harris wins he would be in jail. In politics, it is said, "the only rule is there are no rules." Difficult times for Americans too.

The terminations are part of a large-scale exercise going on all across Fed departments and organisations to reduce wasteful Government expenditure as decided by a Trump in a mess gone berserk, and improve administrative efficiency following the whims of billionaire and his associate Elon MusK and his DOGE. It has not been shared how terminations are going to raise the efficiency bar! It looks like Trump has stolen some of the prescriptions meant for India. But the American problems are quite different.

Suddenly these colonial clerks feel this effortless, little rule will tremendously enhance security and convenience for the railway passengers manifold. More stations will be covered in the next 77 years! (Also See: New Delhi station stampede... What went wrong?)

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