Pig's kidney successfully transplanted in human body at New
York Institute |
In a major breakthrough in the biotechnology of xenotransplant,
a genetically modified “GalSafe” pig's kidney was successfully
transplanted in a brain-dead patient at New York's Langone
Transplant Institute by a team of doctors led by internationally
renowned surgeon Dr Robert Montgomery. This leap forward in
medical research and surgery will potentially revolutionise the
world's healthcare system in the near future.
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NEW YORK, Oct 21: In a major breakthrough in medical science, doctors have
successfully transplanted a pig kidney in a human being. “It had absolutely
normal function,” said Dr Robert Montgomery, internationally renowned surgeon
and director of NYU Langone Transplant Institute who led the operation at the
NYU.
The doctors attached the pig’s kidney to a brain-dead patient who was kept
alive on a life support system. The experiment was approved by the patient’s
family. The surgery took place in September last. USA Today was the first to
publish the transplant.
In the procedure, a single kidney was attached to a pair of blood vessels externally
to the patient’s body to enable observation. After 54 hours, there were no signs
of rejection, and the kidney was functioning well, said the doctors.
“A lot of kidneys from deceased people don’t work right away and take days
or weeks to start,” Dr Montgomery said. “This worked immediately.”
For the surgery, the donor pig was a “GalSafe” pig. GalSafe pigs are pigs genetically
modified for use in drug production, to provide organs and tissues for human
transplant and as meat for those with meat allergies.
The genetic engineering prevents the production of alpha-gal in the pigs, a
carbohydrate that triggers rejection by the human recipient. Alpha-gal is a
sugar found in many mammals that the human immune system identifies as foreign
body and rejects the transplanted organ.
The breakthrough is that the researchers found out what in the animal organ
makes the human immune system to reject it. Then they started engineering the
donor genes to eliminate the rejection factor. Hopefully, the next step will
be the first experimental pig kidney transplant in living people.
This proves that genetically engineered pigs “could potentially be a sustainable,
renewable source of organs."
Research has been going on on transplantation of animal organs in human bodies
for decades especially as there is always a shortage of human donors. Organ
rejection has been the main hurdle in the way of animal organ grafting.
The 17th century attempts to use animal blood for transfusions were the first
attempts in xenotransplantation. Then came an experiment of heart transplant
in a dying infant, which lived 21 days with a baboon heart, a century ago. Gradually
the attention shifted to pigs. One advantage with pigs was that it does not
raise ethical questions as it is reared for food.
The US Food and Drug Administration (FDA) had last year approved the gene alteration
in the pigs as safe for human food consumption and medicine.
Montgomery himself is surviving with a transplant - a human heart from a donor
with hepatitis C he was ready to accept as he was desperately waiting in the
ICU for one to come forward.
There are lakhs of patients in line for a kidney transplant around the world
currently.
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SELECTIONS FROM OUR ARCHIVES |
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Top Govt officer thrashed, kicked inside Bhubaneswar office: Incident sparks a debate
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The incident has triggered a debate on social media whether the officer refused to take orders from a party leader or he was accused of any corruption, some netizens justifying the handling in either case, that Ratnakar was blocking public welfare work! It is true the Govt machinery has been the enemy Number One of the people of this country, existing for itself and for these politicians, for well over seven decades. India will never make an inch of progress - real progress, not make-believe-progress - unless and until this machinery is eliminated.
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UK's House of Commons votes to legalise assisted dying: What it means | |
ANALYSIS: There have been cases of Britons going to Switzerland to get rid of a miserable life. Now once the House of Lords also passes the Terminally Ill Adults (End of Life) Bill, terminally ill Britons can call it quits with the help of a medical practitioner here itself. But the measure when comes into practice, will have very serious social consequences, it is feared. There won't be comparisons, even as tropes in Latin American folklores. The worst case scenario is of those who are not terminally ill also trying to misuse the provision to leave this world early when life with dignity is not available. But that is, in fact, a political question and not a moral imbroglio!
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What caused Air India Boeing 787 crash? Some questions, some answers | |
The CCTV footage and the video circulating on social media do not indicate any serious abnormalities in takeoff or descent, it has been confirmed. The disaster is becoming curiouser and curiouser. The flight path was not curvy. And the aircraft maintained a steady, gliding descent with its nose straight and the wings perfectly level. The pilot's distress call does not specify what prevented lift and climb-out. Here are some expert opinions. The sole purpose is to raise travellers' awareness about air travel.
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Udhampur-Srinagar-Baramulla line brings Kashmir Valley on India's rail map |
- The Udhampur-Srinagar-Baramulla line provides Kashmir with all-weather connectivity and integrates the Valley with the rest of India.
- The saying 'Kashmir to Kanyakumari' is now a dream come true.
- The Chenab bridge on the line, an engineering marvel, is the world's highest
railway bridge, taller than the Eiffel Tower. (Video: File)
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Work done, Elon Musk steps down from DOGE, leaves White House | |
Musk wrote: "My scheduled time as a Special Government Employee comes to an end... The @DOGE mission will only strengthen over time as it becomes a way of life throughout the government." Now on it will be on auto-pilot.
PROGNOSIS: DOGE was prematurely born to protect the country by aborting an impending socio-economic disaster which very few people could see coming.
Although its immediate job was to save American taxpayers billions by slashing waste, eliminating fraud, cutting Government bloat and ensuring utmost efficiency in administration for the good of the people.
(Today's headlines )
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Ailing Asiatic lion Pataudi too dies of bird flu at Kanpur zoo
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Originally from Junagadh, Gujarat, Pataudi was relocated to Etawah Lion Safari in September 2019 before being transferred to Gorakhpur Zoo in 2021. Recently it was receiving treatment for pancreatic and liver infections. After tigress Shakti died in the zoo on May 7 due to bird flu, Pataudi was shifted to Kanpur. Some birds are also reported to have died mysteriously around Gorakhpur. All zoos in UP are closed for fear of a bird flu outbreak.
Three other animals too had died - a tiger, a leopardess and a female wolf. Wolf Bhairavi died last Saturday, leopardess Mona died the Thursday before that and tiger Kesari died on March 30. Some of them had Shakti's symptoms but the cause of death has not been confirmed yet.
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48 tourist destinations closed in Kashmir following Pahalgam terror attack
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As tourist inflow is an indicator of normalcy returning to an erstwhile terrorist infested Valley, the Government has been trying hard to make everything travel-friendly, launching lot many projects and bringing Kashmir on the national rail map that physically completes the process of Kashmir's integration with the rest of India. And that defeats the designs of Pakistan eyeing Kashmir and simply explains a recrudescence of terrorism in J&K.
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Trump slaps ‘kind’, ‘reciprocal’ tariffs on trading partners; a 'lenient' 26% on India!
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ANALYSIS: There is a lot of hue and cry around the world over Trump's tariffs. But tariff, simply put, is a tax. But unlike tax, it affects the exporting country too. Domestic prices will go up for some time. Nothing more will happen, good or bad!
What motivated Trump's newfound policy, apart from being a stunt to justify his existence in the White House, is a false realisation that increased tariff will make foreign goods prohibitive, thereby boosting local production, and create more jobs, and more prosperity will ring in! If that is true, India would have been shining by now: Producing own Rolls-Royce La Rose Noire Droptail and Scotch Whiskies! And what about coconut and palm oil by America!
(Today's headlines )
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Trump signs order to shut Education Dept - And the contrast with India
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PROGNOSIS: It looks a Real New Trump is emerging - courageous, balanced, powerful and disinterested. Determined to save his country from the cliff, he has done quite a few draconian things that will reduce the burden of debts of the Federal entity, like the golden handshake, stopping senseless funding, pulling out of a worthless WHO. Shutting the Education Department is another. On the other hand, running it is also not the Centre's job either (We will convincingly elaborate it in the next chapter).
In India the scene is just the opposite. Centralisation is the core agenda and identity of the ruling dispensation without which it has no existence, or in other words, it exists for that set of schemes only. A realisation of this never dawned upon any Opposition party in 2014 or any time thereafter, what to talk of being able to see it coming 70 years ago! The consequence of all this violation of basic natural law of the universe we cannot predict.
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Sunita, Wilmore's Dragon splashes down in Gulf: What delayed their return? |
THE AMERICAN CONUNDRUM: Political venom has migrated to top echelons in the US. It was reported last year NASA has become politicised, vitiated. But NASA refuted the charge. How Boeing developed a glitch but its unmanned return was smooth. When Suni-Wilmore were stranded last June, why the return was set for February? Because that comes only after January 20! SpaceX called the shots, for itself and for Trump. Then the mission was manipulated for March for a better bargain! In between, what made Elon Musk 'predict' during campaign if Kamala Harris wins he would be in jail. In politics, it is said, "the only rule is there are no rules." Difficult times for Americans too.
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All 80k health workers in US offered $25,000 voluntary buyout: Administering wrong prescriptions!
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The terminations are part of a large-scale exercise going on all across Fed departments and organisations to reduce wasteful Government expenditure as decided by a Trump in a mess gone berserk, and improve administrative efficiency following the whims of billionaire and his associate Elon MusK and his DOGE. It has not been shared how terminations are going to raise the efficiency bar! It looks like Trump has stolen some of the prescriptions meant for India. But the American problems are quite different.
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Neighbours Calling
Bhutan
Nepal
Malaysia
Dubai
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Visit Indian Travel Sites
Goa,
Kerala,
Tamil Nadu,
Andhra Pradesh,
Delhi,
Rajasthan,
Uttar Pradesh,
Himachal Pradesh,
Assam,
Sikkim,
Karnataka,
Madhya Pradesh,
Jammu & Kashmir
Gujarat
Puducherry
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