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CORONAVIRUS CASUALTIES (Oct 28):- GLOBAL:- Total Cases: 4,46,01,770; Total Deaths: 11,76,678 Recovered: 3,26,16,456 BELGIUM:- Total Cases: 3,47,289; Total Deaths: 11,038 BRAZIL:- Total Cases: 54,45,475; Total deaths: 1,58,101 CANADA:- Total Cases: 2,24,653; Total Deaths: 10,023 CHINA:- Total Cases: 85,868; Total Deaths: 4,635 FRANCE:- Total Cases: 11,98,695; Total Deaths: 35,541 GERMANY:- Total Cases: 4,77,203; Total Deaths: 10,347 INDIA:- Total Cases: 80,34,702; Total Deaths: 1,20,524 INDONESIA:- Total Cases: 4,00,483;Total Deaths: 13,612 IRAN:- Total Cases: 5,88,648; Total Deaths: 33,714 ITALY:- Total Cases: 5,89,766; Total Deaths: 37,905 JAPAN:- Total Cases: 98,116; Total Deaths: 1,730 MEXICO:-Total Cases: 9,01,268; Total Deaths: 89,814 NETHERLANDS:- Total Cases: 3,19,991; Total Deaths: 7,202 PHILIPPINES:- Total Cases: 3,75,180; Total Deaths: 7,114 RUSSIA:- Total Cases: 15,63,976; Total Deaths: 26,935 S KOREA:- Total Cases: 26,146; Total Deaths: 461 SPAIN:-Total Cases: 11,94,681; Total Deaths: 35,466 SWEDEN:- Total Cases: 1,17,913 Total Deaths: 5,933 SWITZERLAND:-Total Cases: 1,35,658; Total Deaths: 2,158 UAE:- Total Cases: 1,29,024; Total Deaths: 485 UK:- Total Cases: 9,42,275; Total Deaths: 45,675; US:- Total Cases: 90,86,312; Total Deaths: 2,32,709 - India Travel Times.Com   [Estd: 1998]       * * *    Travel, More Travel, Travel Means A Million Things     * * *    
Russian vaccine may produce antibodies that can worsen corona infection, warn experts
Russian President Putin's daughter has been inoculated with two jabs of Sputnik V. But that does not deter experts world over from going against Sputnik V as it has not completed all the prescribed clinical trials to test its safety, efficacy and side-effects. A top pulmonologist has quit the Health Ministry for "rushing" the vaccine while a leading Russian virologist says a wrong vaccine produces wrong antibodies that only raises the intensity of the viral attack.

MOSCOW, Aug 15: Medical experts within Russia and abroad and the WHO have questioned the ethical validity of releasing the inadequately tested vaccine, Sputnik V, jointly developed by Moscow's Gamaleya Research Institute and the Russian Defence Ministry for inoculation of the public.

One of Russia's top pulmonologists has quit in protest against what he called "rushing" of the vaccine in violation of the medical ethics on human trials. Prof Alexander Chuchalin said, "It is a gross violation of medical ethics." He tried to block the registration of the vaccine on safety grounds. Failing, he quit the ethics council of the Russian Health Ministry.

The two leading doctors involved in the development of the vaccine, Prof Alexander Gintsburg, director of Gamaleya Research Centre, and Prof Sergey Borisevich, virology expert, have come under attack for flouting medical ethics by rushing the vaccine into production without the prescribed trials.

Russia is the first country to register a vaccine against coronavirus but experts say its safety, efficacy and side-effects have not been tested fully through all the stages of human trials.

Russia's leading virologist and former head of infectious diseases centre at the Vector Institute, Alexander Chepurnov, says use of a wrong vaccine increases the severity of a virus. It depends on what antibodies the vaccine creates. With certain antibodies the viral infection can intensify.

The WHO says Russia has not completed the Phase III human trials. Phase III trial involves wide-scale testing with thousands of participants.

According to Prof Chuchalin, it is yet to complete advance stage trials. Go-ahead was given for production without completing the Phase III trials in which thousands of volunteers are given the vaccine to check its side-effects and immune system response it induces.

Meanwhile, Russian President Vladimir Putin's daughter has been inoculated with two jabs. Philippine President Rodrigo Duterte has offered to take a shot. He said: "When the vaccine arrives I will have myself injected in public."

President Vladimir Putin had announced on Tuesday that Russia had become the first country to grant regulatory approval to a covid vaccine, which showed "stable immunity" against the new coronavirus and had "passed all the necessary checks". Putin said his daughter had received the two jabs. But did not say which of his two daughters, Maria and Katerina, received the vaccine. He said the vaccination will be voluntary. Mass vaccination may begin in October. Large-scale production will start in September. Now it is being given to health workers.

It is based on a proven vaccine against adenovirus that causes the common cold. The Russian Health Ministry says it will provide immunity from SARS-CoV-2 for two years. However, the results of trials have not been made public. And there is no transparency.

Called viral vector vaccine (it employs another virus), it is administered in two doses. It has two serotypes of human adenovirus, carrying an S-antigen of the new coronavirus. It will enter the human cell and produce an immune response.

It has been named "Sputnik V" in homage to the world's first satellite launched by the Soviet Union.

There are more than 200 vaccine candidates in the world being developed and tried, with at least 24 in the human clinical trial phase, according to the WHO.

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