ICMR writes obituary of a stillborn convalescent plasma therapy
In fact, the convalescent plasma therapy is a century old
proposal, still we could not so far try to conclusively prove if it
can cure infections! Now caught in the middle of a global
healthcare crisis caused by a ferocious killer coronavirus, which
has no known cure, the ICMR launched a three-month study trial
in hospitals across the country. It found that the CP therapy does
not hold water! (More...)
by RM NAIR
NEW DELHI, Sept 9: In the absence of a medicine for coronavirus since it is
a new disease, doctors have been repurposing existing medicines symptomatically
for which they have the dicretionary powers, but how come politicians the world
over making public announcements reeling out brand names from pharmacopoeia
as each one's discovery for corona cure. This was definitely a collusion to
share the billions the pharma sharks could mint. And they are doing. Else why
couldn't you use at least one of those medicines and save lakhs of lives? We
are into the eighth month! And still groping in the dark!
The reality: Unlike the food pipe and the digestive system that delivers nutrients
to the body, the respiratory track and the lungs delivering oxygen to the system
are difficult to access and deal with in case of infections like tuberculosis,
coronavirus, etc. So much so, these ailments become life-threatening.
As for coronavirus devastating the world for the last eight months, an alternative
therapy called convalescent plasma therapy was mooted four months ago as the
Chinese found it effective, but has not so far been conclusively confirmed so
in trials on patients anywhere else in the world. In this therapy, convalescent plasma collected by apheresis technology is transfused into the patients to create immunity.
In India, various hospitals started administering the alternative at the instance of the Union Health Ministry. It was at
this point that the ICMR initiated trials in collaboration with various hospitals
to confirm the status of the new therapy. In fact, it was not a new therapy.
This had cropped up during the Spanish flu of 1918-20 but till today there has
not a final word about it.
And now, after intensive trials and study, the ICMR has made the announcement:
Convalescent plasma therapy will not do any good in coronavirus patients. In
the therapy, plasma containing antibodies is drawn from the blood of the patient
who has recovered from coronavirus and transfused into a patient to develop
appropriate immunity to fight the infection.
The ICMR said, "The ‘open-label parallel-arm phase II multicentre randomized
controlled trial’ (PLACID Trial) was conducted across 39 public and private
hospitals across India between April 22 and July 14 to find the effectiveness
of convalescent plasma (CP) for the treatment of COVID-19."
It found that the CP therapy does not help in reducing mortality or progression
of the infection to a severe stage. The study covered 464 moderately ill coronavirus
infected hospitalised patients.
The Union Health Ministry had on June 27 allowed the hospitals in the country
the use of the unconfirmed convalescent plasma for treating coronavirus patients
leading to massive irregularities.
“The CP was not associated with a reduction in mortality or progression to
severe COVID-19,” the ICMR study said.
The pilots struggled with Emerson to thwart a shut-off as he reached for
the T-handles (see pix). Later he admitted to police he had taken
psychedelic mushrooms and had a "nervous breakdown."
Doctors reasoned how the incidence of heart attacks is spiking over time and
advise the simple way to play safely is to take a break and rehydrate
yourself.
But how come ten people, including children, die of cardiac arrest at
Garba in 24 hours, and that at different places of Gujarat? Garba had been going on
for six days, and every year it is celebrated.
Shocking news from the UK: Leading grocers have started bribing policemen with free food and drinks to persuade them to take action against shoplifters.
Shoplifting has risen by about 27 per cent in 10 major cities across the UK
this year. The cost of retail crime last year was $2.15 billion. Besides, “We
are seeing organised gangs threatening staff with weapons and emptying
stores," Helen Dickinson, chief executive of the British Retail Consortium,
said. Data shows that the police failed to respond to 73 per cent of serious
retail crimes that included assault and abuse of workers, apart from
shoplifting.
Harris said hip-hop is “the ultimate American art form” that “shapes every
aspect of American popular culture.” “Hip-hop culture is American
culture,” she said in a talk at her official residence at the US Naval
Observatory in Washington, D.C.
The social media had mixed reaction. There was much appreciation that
she dances better than any VP in American history. But some called her
"moves" as “cringe” while others did not like her pink pants - "pink pants
don’t look good.” In fact, her ensembles have always been incongruous.
"Let’s see how the (Governor's) Vice-Chancellors are given salary."
Mamata's extreme statements will put the Marxist Government in Kerala,
which is also facing similar issues, to shame. Has she begun the
countdown for a war on the streets?
It's true Mamata has come to see a conspiracy to demolish the established systems across the country, but lacks the ability to foresee what exactly is being pushed.
Brandishing a sword, Mahant Paramhans told reporters on Tuesday he
himself will behead MK Stalin's son for his remarks against Sanatan
Dharma in case nobody came forward to accept his offer he made in his
video. Udhayanidhi reacted to the saint's Monday video, "I will speak
more. I am the grandson of the artist who put his head on the rail track for
Tamil Nadu."
Somanath elaborated, "I am an explorer. I explore the Moon. I explore the inner
space. So it's a part of the journey of my life to explore both science and
spirituality. So I visit many temples and I read many scriptures. So try to find the
meaning of our existence and our journey in this cosmos. So it's a part of the
culture that we are all built to explore, find out the inner self as well as outer
self. So for the outer, I do science, for the inner I come to temples." (See videos)
Rao the mathematical legend had fathered the path-breaking Rao-Blackwell
theorem, one of the most important theorems in mathematical statistics, at the
age of 25. That brought him global fame. He is also famous for his Cramér-Rao
Bound inequality theorem relating to quality of estimators in statistics which has
had a profound bearing on applications of modern economics and several other
diverse fields. Simply put, with the pioneering statistician computation became a
tool to analyse even socio-economic challenges of modern times.
The alleged incident has received such a flash publicity that a standardised
city's hugely middle class population will have second thoughts about eating
outside for some time. Now everything on the table looks suspicious!
“All subjects directly connected to the people should be shifted to the State List. Particularly the subject of education. Only if this is done can cruel exams like NEET be abolished,” Stalin said. Education was moved from the State List to the Concurrent List with the 42nd Constitution Amendment made by the Central Government in 1976.
Decentralisation has been at the core of Tamil politics since the times of CN Annadurai. Stalin indicated there will be political changes in the offing.
TAILPIECE: While the Centre and the States are at loggerheads, it takes a
different cognitive acumen to know that entrance tests are not the way for
students' admission to courses.
A University of Florida Professor, Harrison Hove who was on the flight, posted
on social media that the incident was "terrifying." He said, "I've flown a lot. This
was scary ... The photos cannot capture the burning smell, loud bang or ear
pops ... Something failed midflight and depressurized the cabin."
As recently as Tuesday Craig Robertson had posted on Facebook: "Perhaps
Utah will become famous this week as the place a sniper took out Biden the
Marxist." Biden was scheduled to make his first visit to Utah as President
Wednesday afternoon.
Let's Go! The legal immigrants should be allowed the flexibility
to change jobs and travel without obstacles. Doing away with the country cap
on Green Cards only can do this easily.
Bureaucratic delays in the US legal immigration system are also a drag on
the country's economy while leaving so many families in limbo, the Congressmen
argued.
In fact, the country cap was introduced to ensure diversity of immigrants
as well as to prevent monopoly by any one country like China leading to distortions
in the American culture and politics in course of time.
In any which case, it is high time the US straightened its convoluted immigration
laws for their own convenience and to allow the immigrants their basic rights!
Maruti is recalling 87,599 S-Presso and Eeco vehicles to inspect and possibly
replace parts in the steering system. All reputed companies around the
world do recall their products when a defect comes to light.
Meanwhile, a question arises why just in about a year so many accidents have
taken place involving Mercedes sent to India while the car has won safety awards
abroad? In most cases, the vehicle collided with divider, while manoeuvring a
turn. Was there a split second delay in the steering system coming to a grip
when at high speed? Did anybody in India bother to study a pattern in several
of these accidents that took place one after other?
Former Tata Sons chairman Cyrus Mistry died when his Mercedes-Benz-SUV hit
a divider in Gujarat. Cricketer Rishabh Pant's Mercedes-Benz-SUV rammed a divider
in Uttarakhand and smashed. It went up in flames but he escaped with injuries.
Brother of PM Narendra Modi, Prahlad Modi's Mercedes-Benz-SUV met with a similar
accident in Mysuru. And many more.
Experts blame violation of the Visual Flying Rules (VFR) for most of the
chopper crashes in the mountains as the leading cause. VFR means fly only
visually - because of the lack of navigation aids in remote areas or unreliability
of GPS-like aids in hilly terrains or a remote manipulation of instruments
in cases of sabotage - as the topography plays havoc especially in the monsoon
(mid-June to September).
Even when VFR is followed, most crashes occur due to CFIT (Controlled Flight
into Terrain) - that is, everything else is OK but the aircraft collides with
hills or trees hidden by the clouds. This also occurs mostly in the monsoon.
On Tueday with Manang, the chopper was brand new, pilot was highly experienced.
But it hit an 'invisible' tree and then crashed against a hillside. This
CFIT occurred when the pilot tried to dodge patches of clouds even as he was
following the VFR.
Simply put, everyone knows flying in the hills during the monsoon is risky,
but the companies want to make more money in any which case. This type of
tragedy is very frequently invited in the Indian hill State of Uttarakhand
as well, where pilots are even made to fly without the mandatory rest.
Curfew was clamped on areas in Paris on Thursday lasting till Monday. The
police apprehend an escalation of volence in the coming days. There will be
"actions targeted at the forces of order and the symbols of the State", they
said.
Under present law, the police have brute powers to deal with traffic violators.
Young Nahel was shot point-blank by a cop for purported traffic violation
and an anticipated crime.
Way back when on June 20 EST after searches were launched, India Travel
Times had, on an analysis of the data available, indicated the probability of
Titan undergoing a sudden and massive implosion (inward collapse) at great
depths. (SEE: Titanic expedition goes missing: A ray of hope from
sounds of bang)
Now videos taken by a Canadian robot that reached the floor on
Thursday evening, June 22, has confirmed it. The fragments are lying
scattered. Horizon Arctic's ROV robot found the debris 1600 ft from Titanic
bow.
The submersible imploded at 500 metres above sea bed, if we go by our
calculations. The water pressure it had to withstand at that point was 2,345 kg
per sq inch. The hull was not built to take that, as per the court cases fought by
concerned people at the time of building the sub and going by the details revealed
in the cancellation of booking by at least one ocean expert.