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CORONAVIRUS CASUALTIES (Oct 25):- GLOBAL:- Total Cases: 4,30,62,591; Total Deaths: 11,56,270 Recovered: 3,17,42,791 BELGIUM:- Total Cases: 3,05,409; Total Deaths: 10,737 BRAZIL:- Total Cases: 53,81,224; Total deaths: 156,926 CANADA:- Total Cases: 2,13,959; Total Deaths: 9,922 CHINA:- Total Cases: 85,790 ; Total Deaths: 4,635 FRANCE:- Total Cases: 10,86,497; Total Deaths: 34,645 GERMANY:- Total Cases: 4,29,893; Total Deaths: 10,123 INDIA:- Total Cases: 78,73,664; Total Deaths: 1,18,621 INDONESIA:- Total Cases: 3,89,712;Total Deaths: 13,299 IRAN:- Total Cases: 5,68,896; Total Deaths: 32,616 ITALY:- Total Cases: 5,04,509; Total Deaths: 37,210 JAPAN:- Total Cases: 96,534; Total Deaths: 1,711 MEXICO:-Total Cases: 8,86,800; Total Deaths: 88,743 NETHERLANDS:- Total Cases: 2,91,254; Total Deaths: 7,046 PHILIPPINES:- Total Cases: 3,70,028; Total Deaths: 6,977 RUSSIA:- Total Cases: 15,13,877; Total Deaths: 26,050 S KOREA:- Total Cases: 25,836; Total Deaths: 457 SPAIN:-Total Cases: 11,10,372; Total Deaths: 34,752 SWEDEN:- Total Cases: 1,10,594 Total Deaths: 5,933 SWITZERLAND:-Total Cases: 1,03,653; Total Deaths: 2,083 UAE:- Total Cases: 1,25,123; Total Deaths: 477 UK:- Total Cases: 8,54,010; Total Deaths: 44,745; US:- Total Cases: 88,33,384; Total Deaths: 2,30,091 - India Travel Times.Com   [Estd: 1998]       * * *    Travel, More Travel, Travel Means A Million Things     * * *    
Oxford vaccine trial is back with a bang - UK regulator gives safety clearance
AstraZeneca pharma giant has resumed clinical trials of the Oxford coronavirus vaccine, AZD1222, after a pause clamped last week over development of an illness, transverse myelitis, in a participant. The final trials were going on in several countries like the UK, US and India. The trials resumed after safety clearance from the UK Medicines and Healthcare products Regulatory Agency (MHRA).

The adverse episode of transverse myelitis, a neurological disorder of the spinal cord, could be caused by a coincidental viral infection or an autoimmune attack on the myelin in the spinal column on the lines of MS or just like in bowel dysfunction (IBS) or could be even a minor cytokine storm, not linked to the vaccine.

NEW DELHI, Sept 13: The Oxford vaccine for coronavirus on Saturday resumed final clinical trials halted across several countries due to the development of an illness in one of the tens of thousands of participants in its UK leg last week. The clearance has come in lightning speed considering the emergency situation, even as predictions from various quarters did not see any chance of resumption of the trials untill next year.

The sanction from the UK regulator, Medicines and Healthcare products Regulatory Agency (MHRA), followed the recommendations of an independent safety review committee, which investigated the episode.

"Clinical trials for the AstraZeneca Oxford coronavirus vaccine, AZD1222, have resumed in the UK following confirmation by the Medicines Health Regulatory Authority (MHRA) that it was safe to do so," the AstraZeneca pharma giant said in a statement.

AstraZeneca, the British-Swedish pharma company, has been participating in the trial and production of the AZD1222 COVID-19 vaccine with the Oxford University Jenner Institute, which had developed the vaccine.

The illness in one participant in a UK leg that led to the pause in the final phase of trials of the Oxford vaccine all over the world has now been revealed as transverse myelitis, a neurological disorder, that may or may not be an isolated case of reaction to the vaccine. AstraZeneca's chief executive, Pascal Soriot, had told medical journal Stat News that the illness has been diagnosed as transverse myelitis but did not disclose further details, may be because of patient's confidentiality issue. Possibly the adverse event was not linked to the vaccine as the pause has been lifted with immediate effect.

Eruption of various symptoms is quite common in the course of development of a vaccine. And temporary pauses in trials are also not uncommon in medical research. Besides, a stray episode could be coincidental as its possibility is higher when thousands of volunteers are participating, said AstraZeneca. It may not have anything to do with the vaccine at all.

What is transverse myelitis

Transverse myelitis could be viral infection. It could also be an autoimmune attack on the myelin in the spinal column on the lines of MS or just like in bowel dysfunction (IBS) etc or a minor cytokine storm occurring as a blind response to the introduction of the vector or even a RNA simulator in the vaccine. The vaccine candidate had already passed all the stages of safety trials so far.

Transverse myelitis can give pain in the neck or back or numbness in the legs etc. It can progressively lead to sensorimotor myelopathy as well. Administration of steroids is the common treatment.

The Oxford vaccine Phase 3 final clinical trials on around 30,000 participants have been going on in the US, the UK, Brazil, South Africa and India.

Nearly 180 vaccine candidates are being developed around the world but none has yet completed all the clinical trials, according to WHO statistics. The Oxford vaccine was considered as number one to hit the market.

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