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CORONAVIRUS CASUALTIES (Oct 25):- GLOBAL:- Total Cases: 4,30,62,591; Total Deaths: 11,56,270 Recovered: 3,17,42,791 BELGIUM:- Total Cases: 3,05,409; Total Deaths: 10,737 BRAZIL:- Total Cases: 53,81,224; Total deaths: 156,926 CANADA:- Total Cases: 2,13,959; Total Deaths: 9,922 CHINA:- Total Cases: 85,790 ; Total Deaths: 4,635 FRANCE:- Total Cases: 10,86,497; Total Deaths: 34,645 GERMANY:- Total Cases: 4,29,893; Total Deaths: 10,123 INDIA:- Total Cases: 78,73,664; Total Deaths: 1,18,621 INDONESIA:- Total Cases: 3,89,712;Total Deaths: 13,299 IRAN:- Total Cases: 5,68,896; Total Deaths: 32,616 ITALY:- Total Cases: 5,04,509; Total Deaths: 37,210 JAPAN:- Total Cases: 96,534; Total Deaths: 1,711 MEXICO:-Total Cases: 8,86,800; Total Deaths: 88,743 NETHERLANDS:- Total Cases: 2,91,254; Total Deaths: 7,046 PHILIPPINES:- Total Cases: 3,70,028; Total Deaths: 6,977 RUSSIA:- Total Cases: 15,13,877; Total Deaths: 26,050 S KOREA:- Total Cases: 25,836; Total Deaths: 457 SPAIN:-Total Cases: 11,10,372; Total Deaths: 34,752 SWEDEN:- Total Cases: 1,10,594 Total Deaths: 5,933 SWITZERLAND:-Total Cases: 1,03,653; Total Deaths: 2,083 UAE:- Total Cases: 1,25,123; Total Deaths: 477 UK:- Total Cases: 8,54,010; Total Deaths: 44,745; US:- Total Cases: 88,33,384; Total Deaths: 2,30,091 - India Travel Times.Com   [Estd: 1998]       * * *    Travel, More Travel, Travel Means A Million Things     * * *    
Heparin: Breakthrough in research for medicine for coronavirus
The latest development is that a medicine surrounding heparin may emerge as the solution for coronavirus. Heparin is an anticoagulant. A broad anti-viral treatment with heparin and heparin-like drugs may also be the solution to all future zoonotic coronaviruses and other viral pathogens.

NEW DELHI, Sept 22: When is the pandemic going to end? In the absence of a medicine for coronavirus, some people are earnestly hoping for a vaccine to come. But for a vaccine to be developed in normal course it takes years and sometimes a decade. But considering the emergency with coronavirus raging across the world, it may be expedited. Still those close to the development say mass vaccination many not be achieved before 2021 end.

An alternative situation to contain the epidemic is when 50-60 per cent of the population gets infected so as to generate what is called herd immunity.

Meanwhile, a silent race to find a drug is going on in labs around the world. A new discovery has opened up the possibilities of finding a medicine for coronavirus by disrupting the virus' ability to bind the cells in the lungs in order to make its entry that causes the infection. This may even be achieved potentially by using a repurposed drug.

It had earlier been discovered in the month of January that a receptor called ACE2 (angiotensin-converting enzyme 2) that is a molecule in the shape of a door knob on the surface of lung cells is used by the protein spike of the virus to bind with the cell.

Now Californian researchers have found that a coreceptor called heparan sulfate, a carbohydrate molecule, also on the surface of the cells, acts like an adhesive for the viral spike to firmly attach the pathogen to the cell to facilitate fusion and entry.

Heparin is a well-known anti-clotting drug used on several medical occasions. It is also found to have many other benefits. Clinically, heparin as an anti-inflammatory agent has also been seen helpful in diseases like inflammatory bowel disease, asthma, reactive airways disease and acute coronary syndrome.

The California University study says the discovery of the role of heparan sulfate opens up new possibilities for treating covid by disrupting the virus' ability to bind the carbohydrate. So they are looking for a drug, possibly an existing drug to be repurposed.

The University of California San Diego School of Medicine researchers have been credited with the finding that without a carbohydrate called heparan sulfate the virus cannot interact with ACE2. It is a coreceptor for viral entry.

The team demonstrated two approaches that can reduce the ability of SARS-CoV-2 to infect human cells cultured in the lab by approximately 80 to 90 percent: 1) removing heparan sulfate with enzymes or 2) using heparin as a bait to lure and bind the coronavirus away from human cells.

With this viral entry mechanism established, the researchers are on the job of finding a way to disrupt it with an enzyme that neutralises heparan sulfate from cell surface.

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